Photodynamic Therapy of Oral Cancer and Novel Liposomal Photosensitizers
نویسندگان
چکیده
Photodynamic therapy facilitates the selective destruction of cancer tissue by utilizing a photosensitizer drug, light near absorbance wavelength and oxygen. Methylene Blue, 5-aminolevulinic acid (the precursor photosensitizer, protoporphyrin IX), porphyrin, Foscan, Chlorin e6, HPPH have been used successfully as photosensitizers in treatment oral verrucous hyperplasia, leukoplakia, lichen planus, head neck squamous cell carcinoma. “Theranostic” liposomes can deliver contrast agent for magnetic resonance imaging image-guided photodynamic cancer. Liposomes incorporating be targeted to surface markers overexpressed on cells. Novel porphyrinoids developed our laboratories that are highly effective photosensitizers. Tribenzoporphyrazines encapsulated cationic produced IC50 values up 50 times lower compared free It is anticipated targeting these drugs stem cells, using upconversion nanoparticles near-infrared irradiation tumors activate photosensitizers, overcoming tumor hypoxia will enhance efficacy accessible sources.
منابع مشابه
Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy.
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ژورنال
عنوان ژورنال: Oral
سال: 2023
ISSN: ['2673-6373']
DOI: https://doi.org/10.3390/oral3030023